RNR polimerazės III promotoriai Jungiasi TFIIIA Jungiasi TFIIIC Jungiasi TFIIIC Jungiasi TFIIIC TFIIIA ir TFIIIC padeda prisjungti TFIIIB transkripcijos faktoriui

RNR polimerazės II promotoriai Šis promotorius dažniausiai naudojamas embrioninio vystymosi metu

Kompleksą gali sudaryti virš 85 polipeptidų

Removes acetyl groups, thereby restoring a tighter interaction 1. Covalent modification of histones Amino terminals of histones are modified in various ways Acetylation; phosphorylation; methylation Adds acetyl groups, thereby loosening the interaction between histones and DNA Removes acetyl groups, thereby restoring a tighter interaction

2. ATP-dependent chromatin remodeling The energy of ATP is used to alter the structure of nucleosomes and thus make the DNA more accessible Proteins are members of the SWI/SNF family Acronyms refer to the effects on yeast when these enzyme are defective Mutants in SWI are defective in mating type switching Mutants in SNF are sucrose non-fermenters These effects may significantly alter gene expression

Skirtingų organizmų SWI/SNF kompleksai

Chromatino surinkimo ir transkripcinės aktyvacijos, dalyvaujant SWI–SNF, modelis